Insulin secretion: Feed-forward control of insulin biosynthesis?

被引：38

作者：

Rutter, GA ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(99)80277-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has long been accepted wisdom that insulin secreted from islet beta cells has either no effect, or an inhibitory feedback effect, on insulin synthesis and secretion. Recent work suggests, instead, that secreted insulin acts directly on beta cells, via its own receptor, to enhance insulin production in an autocrine feed-forward loop. (C) Elsevier Science Ltd ISSN 0960-9822.

引用

页码：R443 / R445

页数：3

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