5-HT2A receptor and bipolar affective disorder: Association studies in affected patients

被引：48

作者：

Arranz, MJ

Erdmann, J

Kirov, G

Rietschel, M

Sodhi, M

Albus, M

Ball, D

Maier, W

Davies, N

Franzek, E

Abusaad, I

Weigelt, B

Murray, R

ShimronAbarbanell, D

Kerwin, R

Propping, P

Sham, P

Nothen, MM

Collier, DA

机构：

[1] UNIV BONN,INST HUMAN GENET,D-53111 BONN,GERMANY

[2] UNIV BONN,DEPT PSYCHIAT,D-53127 BONN,GERMANY

[3] MENTAL STATE HOSP HAAR,D-85540 HAAR,GERMANY

[4] UNIV WURZBURG,DEPT PSYCHIAT,D-97080 WURZBURG,GERMANY

[5] TECH UNIV DRESDEN,DEPT PSYCHIAT,D-01307 DRESDEN,GERMANY

来源：

NEUROSCIENCE LETTERS | 1997年 / 224卷 / 02期

关键词：

single strand conformation polymorphism; bipolar affective disorder; 5-HT2A receptor gene;

D O I：

10.1016/S0304-3940(97)13456-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to investigate the possible involvement of genetic variation in serotonin receptors in the aetiology of bipolar affective disorder. The 5-HT2A receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. Four polymorphisms (two structural changes, Thr25Asn and His452Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected. No novel polymorphisms were found in patients with bipolar affective disorder. These polymorphisms were genotyped in a sample of 129 patients and 252 controls of German origin and 176 patients and 182 controls of British origin. No strong associations were found between any of these polymorphisms and bipolar affective disorder. Genetic variation at the 5-HT2A receptor gene does not play a major role in the pathogenesis of the disorder. (C) 1997 Elsevier Science ireland Ltd.

引用

页码：95 / 98

页数：4

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