Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

被引：15

作者：

Howard, Peter F. ^{[1
,2
]}

McCaw, James M. ^{[1
,2
]}

Richmond, Peter C. ^{[3
,4
]}

Nissen, Michael ^{[5
,6
]}

Sloots, Theo ^{[5
,6
]}

Lambert, Stephen B. ^{[5
,6
]}

Lai, Michael ^{[7
]}

Greenberg, Michael ^{[7
]}

Nolan, Terry ^{[1
,2
]}

McVernon, Jodie ^{[1
,2
]}

机构：

[1] Univ Melbourne, Murdoch Childrens Res Inst, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Melbourne Sch Populat Hlth, Parkville, Vic 3010, Australia

[3] Univ Western Australia, Sch Paediat & Child Hlth, Perth, WA 6009, Australia

[4] Princess Margaret Hosp Children, Telethon Inst Child Hlth Res, Perth, WA, Australia

[5] Univ Queensland, Queensland Paediat Infect Dis Lab, Queensland Childrens Med Res Inst, Brisbane, Qld, Australia

[6] Univ Queensland, Sir Albert Sakzewski Virus Res Ctr, Queensland Childrens Hlth Serv, Brisbane, Qld, Australia

[7] CSL Ltd, Clin Res & Dev, Parkville, Vic, Australia

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2013年 / 7卷 / 03期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Epidemiology; human; influenza; influenza vaccines; picornavirus infection; respiratory tract infection; RESPIRATORY VIRUSES; HUMAN METAPNEUMOVIRUS; HUMAN RHINOVIRUSES; COST-EFFECTIVENESS; VIRAL-INFECTION; RT-PCR; CHILDREN; EXACERBATIONS; CORONAVIRUS; IDENTIFICATION;

D O I：

10.1111/j.1750-2659.2012.00395.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Viral respiratory infections are associated with significant morbidity and mortality. Many new aetiological agents have been described recently. Objectives We looked for respiratory viruses in a population-based sample of healthy adults with influenza-like illness (ILI). We investigated host and spatio-temporal associations with virus isolation and host, spatio-temporal and virus associations with self-reported symptoms. Patients/Methods We recruited 586 participants experiencing 651 illness episodes from a population of healthy adults enrolled in an influenza vaccine effectiveness trial. At ILI assessment visits, a respiratory swab was collected and tested for viruses using a combination of polymerase chain reaction (PCR) assays. Participants also completed a questionnaire detailing their clinical course in 336 episodes. Results Of 643 samples analysed, a virus was identified in 44%. Half were picornaviruses, with influenza and coronaviruses the next most common. Individuals with influenza were significantly less likely to have been immunised than the reference (virus negative) population (OR=0 center dot 52 (0 center dot 31, 0 center dot 87) P=0 center dot 01). The mean symptom score (95% CI) reported by individuals with influenza was significantly higher than in all other episodes [Influenza: 10 center dot 2 (9 center dot 4, 10 center dot 9); Other: 7 center dot 4 (7 center dot 2, 7 center dot 7); Difference (95% CI): 2 center dot 5 (1 center dot 5, 3 center dot 5); P<0 center dot 001]. In an analysis restricted to influenza-positive cases, the symptom score was not attenuated by vaccination. Conclusions Our findings indicate that a greater number of symptoms are displayed by individuals presenting with influenza confirmed ILI compared with other agents that cause ILI. While influenza vaccination reduced the probability of influenza virus detection, symptom score for influenza-positive ILI was not attenuated.

引用

页码：330 / 339

页数：10

共 42 条

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