Captodative olefins: methyl 2-aryloxy-3-dimethylaminopropenoates and their application in a new synthesis of benzofurans

被引：37

作者：

Cruz, MD ^{[1
]}

Tamariz, J ^{[1
]}

机构：

[1] Escuela Nacl Ciencias Biol, Dept Quim Organ, Inst Politecn Nacl, Mexico City 11340, DF, Mexico

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 11期

关键词：

captodative olefins; 2-aryloxy-3-dimethylaminopropenoates; benzofurans; cyclization; Lewis acid catalysis;

D O I：

10.1016/j.tetlet.2004.01.073

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The beta-substituted captodative olefins methyl 2-aryloxy-3-dimethylaminopropenoates 4a-h were synthesized, via amino-methylenation of the corresponding 2-phenoxyacetic esters 9a-h. Lewis acid promoted intramolecular cyclization of alkenes 4 led to benzofurans 7a-h, in an efficient synthetic approach to the benzofuran frame. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2377 / 2380

页数：4

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