Mammalian Base Excision Repair: the Forgotten Archangel

被引：276

作者：

Dianov, Grigory L. ^{[1
]}

Huebscher, Ulrich ^{[2
]}

机构：

[1] Univ Oxford, Gray Inst Radiat Oncol & Biol, Dept Oncol, Oxford OX3 7DQ, England

[2] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / 06期

基金：

瑞士国家科学基金会; 英国医学研究理事会;

关键词：

DNA-POLYMERASE-BETA; STRAND BREAK REPAIR; LIGASE III; POLY(ADP-RIBOSE) POLYMERASE; PATCH REPAIR; DAMAGE; XRCC1; GLYCOSYLASE; REQUIREMENT; COMPLEX;

D O I：

10.1093/nar/gkt076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of basic components for fast and accurate repair, but also requires temporal and spatial coordination of BER and cell cycle progression to prevent replication of damaged DNA. The major goal of this review is to critically examine controversial and newly emerging questions about mammalian BER pathways, mechanisms regulating BER capacity, BER responses to DNA damage and their links to checkpoint control of DNA replication.

引用

页码：3483 / 3490

页数：8

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