New insights into the post-translational modification of Toll-like receptor signaling molecules

被引：7

作者：

Dunne, A ^{[1
]}

O'Neill, L ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2005年 / 11卷 / 06期

关键词：

TLRs; post-translational modification; phosphorylation; ubiquitination; de-ubiquitination;

D O I：

10.1179/096805105X58742

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deregulation of Toll-like receptor (TLR) mediated responses can have devastating effects on the host if left unchecked. It is, therefore, critical that control is exerted at several levels. In this review, we discuss post-translational modification of TLRs and their associated signaling molecules as one such means of control. In particular, we focus on the phosphorylation, ubiquitination and de-ubiquitination of various components of TLR signaling pathways.

引用

页码：325 / 332

页数：8

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