Functional status, heart rate, and rhythm abnormalities in 521 Fontan patients 6 to 18 years of age

被引：51

作者：

Blaufox, Andrew D. ^{[1
]}

Sleeper, Lynn A. ^{[2
]}

Bradley, David J. ^{[3
]}

Breitbart, Roger E. ^{[4
,5
]}

Hordof, Allan ^{[6
]}

Kanter, Ronald J. ^{[7
]}

Stephenson, Elizabeth A. ^{[8
]}

Stylianou, Mario ^{[9
]}

Vetter, Victoria L. ^{[10
]}

Saul, J. Philip ^{[1
]}

机构：

[1] Med Univ S Carolina, Charleston, SC 29425 USA

[2] New England Res Inst, Watertown, MA 02172 USA

[3] Univ Utah, Primary Childrens Med Ctr, Salt Lake City, UT USA

[4] Childrens Hosp Boston, Boston, MA USA

[5] Harvard Univ, Sch Med, Boston, MA 02115 USA

[6] Columbia Univ, Childrens Hosp, New York, NY USA

[7] Duke Univ, Sch Med, Durham, NC USA

[8] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[9] NHLBI, Bethesda, MD 20892 USA

[10] Childrens Hosp, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | 2008年 / 136卷 / 01期

关键词：

D O I：

10.1016/j.jtcvs.2007.12.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Our objective was to determine the relationship between functional outcome and abnormalities of heart rate and rhythm after the Fontan operation. Methods: The National Heart, Lung, and Blood Institute Pediatric Heart Network conducted a cross-sectional analysis of patients who had undergone a Fontan procedure at the 7 network centers. Analysis was based on 521 patients with an electrocardiogram (n = 509) and/or bicycle exercise test ( n 5 404). The Child Health Questionnaire parent report and the oxygen consumption at the anaerobic threshold were used as markers of functional outcome. Results: Various Fontan procedures had been performed: intracardiac lateral tunnel (59%), atriopulmonary connection (14%), extracardiac later tunnel (13%), and extracardiac conduit (11%). Prior volume unloading surgery was performed in 389 patients: bidirectional Glenn (70%) and hemi-Fontan (26%). A history of atrial tachycardia was noted in 9.6% of patients and 13.1% of patients had a pacemaker. Lower resting heart rate and higher peak heart rate were each weakly associated with better functional status, as defined by higher anaerobic threshold (R = -0.18, P = .004, and R = 0.16, P = .007, respectively) and higher Child Health scores for physical functioning (R = -0.18, P < .001, and R = 0.17, P = .002, respectively). Higher anaerobic threshold was also independently associated with younger age and an abnormal P-axis. Resting bradycardia was not associated with anaerobic threshold or Child Health scores. Conclusions: In pediatric patients (6-18 years) after the Fontan procedure, a lower resting heart rate and a higher peak heart rate are each independently associated with better physical function as measured by anaerobic threshold and Child Health scores. However, these correlations are weak, suggesting that other, nonrhythm and nonrate, factors may have a greater impact on the functional outcome of pediatric patients after the Fontan operation.

引用

页码：100 / U87

页数：9

共 26 条

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