Sialyl-Lewis a carrying MUC1 and CD43 mucin-type glycoproteins expressed and secreted from colon carcinoma cells - A role in tumor progression?

被引：1

作者：

Hansson, GC ^{[1
]}

机构：

[1] GOTHENBURG UNIV, DEPT BIOCHEM MED, S-41390 GOTHENBURG, SWEDEN

来源：

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 1997年 / 9卷 / 46期

关键词：

colon cancer; glycoprotein; mucin; NK cell; sialyl-Lewis a;

D O I：

10.4052/tigg.9.211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nature of mucins expressed and secreted from colon cancer tumors is discussed. Two mucin-type molecules, MUC1 and the leukocyte marker CD43 (leukosialin), have been found in a model tumor cell line (COLO 205) as well as in clinical colon cancer cells. The sialyl-Lewis a expressing MUC1 and CD43 mucins can inhibit leukocyte adhesion to E-selectin endothelial cells and also NK cell mediated killing of target cells. The results propose that mucins secreted from tumor cells could interfere with the immune systems possibilities of eliminating tumor cells. The expression of CD43 in colon adenoma and cancer cells could be involved in the tumor progression.

引用

页码：211 / 222

页数：12

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