Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives

被引：89

作者：

Pandeya, SN

Yogeeswari, P

Sriram, D ^{[1
]}

de Clercq, E

Pannecouque, C

Witvrouw, M

机构：

[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

CHEMOTHERAPY | 1999年 / 45卷 / 03期

关键词：

isatin; Schiff's base; N-Mannich base; anti-HIV activity; MTT assay;

D O I：

10.1159/000007182

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of about 12 new compounds of Mannich bases of isatin against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT, In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.

引用

页码：192 / 196

页数：5

共 9 条

[1] AROMATIC SULFONIC ACIDS AS VIRAL INHIBITORS - STRUCTURE-ACTIVITY STUDY USING RHINO, ADENO 3, HERPES SIMPLEX, AND INFLUENZA VIRUSES [J].

AKERFELDT, S ;

WESTIN, G ;

JANSSON, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (07) :596-+

[2] MOLECULAR-CLONING AND POLYMORPHISM OF THE HUMAN IMMUNE-DEFICIENCY VIRUS TYPE-2 [J].

CLAVEL, F ;

GUYADER, M ;

GUETARD, D ;

SALLE, M ;

MONTAGNIER, L ;

ALIZON, M .

NATURE, 1986, 324 (6098) :691-695

[3]

GWALTNEY JM, 1970, P SOC EXP BIOL MED, V133, P1148, DOI 10.3181/00379727-133-34642

[4]

HAFF RF, 1972, P SOC EXP BIOL MED, V141, P475, DOI 10.3181/00379727-141-36801

[5]

HARVEY IS, 1995, J MED CHEM, V38, P4968

[6]

MATSUMOTO S, 1972, P SOC EXP BIOL MED, V139, P455

[7]

POPP DF, 1975, ADV HETEROCYCLIC CHE, V18

[8]

POPVIC M, 1984, SCIENCE, V224, P497

[9]

VARMA R S, 1982, Indian Journal of Pharmaceutical Sciences, V44, P132

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