Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

被引：338

作者：

Robinson, HL ^{[1
]}

Montefiori, DC

Johnson, RP

Manson, KH

Kalish, ML

Lifson, JD

Rizvi, TA

Lu, S

Hu, SL

Mazzara, GP

Panicali, DL

Herndon, JG

Glickman, R

Candido, MA

Lydy, SL

Wyand, MS

McClure, HM

机构：

[1] Yerkes Reg Primate Res Ctr, Atlanta, GA 30329 USA

[2] Duke Univ, Med Ctr, Durham, NC 27710 USA

[3] New England Reg Primate Res Ctr, Southborough, MA 01772 USA

[4] Harvard Univ, Sch Med, AIDS Res Ctr, Southborough, MA 01772 USA

[5] GTC Mason Labs, Worcester, MA 01608 USA

[6] Ctr Dis Control, Atlanta, GA 30333 USA

[7] NCI, Frederick Canc Res Ctr, Frederick, MD 21702 USA

[8] Univ Texas, MD Anderson Canc Ctr, Bastrop, TX 78802 USA

[9] Univ Massachusetts, Med Ctr, Div Infect Dis, Worcester, MA 01655 USA

[10] Univ Washington, Reg Primate Res Ctr, Seattle, WA 98195 USA

[11] Therion Biol, Cambridge, MA 02142 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 05期

关键词：

D O I：

10.1038/8406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.

引用

页码：526 / 534

页数：9

共 49 条

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ANDERSSON S, 1989, J BIOL CHEM, V264, P8222

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