Expression, cellular localization and antibody responses of the African swine fever virus genes B602L and K205R

被引：41

作者：

Gutierrez-Castaneda, B. ^{[2
]}

Reis, A. L. ^{[1
]}

Corteyn, A. ^{[2
]}

Parkhouse, R. M. E. ^{[1
,2
]}

Kollnberger, S. ^{[2
]}

机构：

[1] Gulbenkian Inst Sci, P-2781901 Lisbon, Portugal

[2] Inst Food Res, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England

来源：

ARCHIVES OF VIROLOGY | 2008年 / 153卷 / 12期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1007/s00705-008-0246-z

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Previously, we identified serological immunodeterminants of African swine fever virus (ASFV), including pK205R and pB602L, without homologues in the database. pK205R is expressed as a 33-kD protein from 4 h post-infection onward, initially diffusely distributed throughout cells, and subsequently in viral factories. pK205R was not found in purified virus. Both pK205R and pB602L are recognised by hyperimmune antisera from domestic pigs and bushpigs at late time points after infection, suggesting they may be useful diagnostically to distinguish animals persistently infected with virus.

引用

页码：2303 / 2306

页数：4

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