Strategic pooling of compounds for high-throughput screening

被引：184

作者：

Hann, M ^{[1
]}

Hudson, B ^{[1
]}

Lewell, X ^{[1
]}

Lifely, R ^{[1
]}

Miller, L ^{[1
]}

Ramsden, N ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Biomol Struct Compound Divers & Exploratory, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 1999年 / 39卷 / 05期

关键词：

D O I：

10.1021/ci990423o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bringing new medicines to the market depends on the rapid discovery of new and effective drugs, often initiated through the biological testing of many thousands of compounds in high-throughput screening (HTS). Mixing compounds together into pools for screening is one way to accelerate this process and reduce costs. This paper contains both theoretical and experimental data which suggest that careful selection of compounds to be pooled together is necessary in order to reduce the risk of reactivity between compounds within the pools.

引用

页码：897 / 902

页数：6

共 10 条

[1] Future pathways for combinatorial chemistry [J].