The MPEG effect: Improving asymmetric processes by simple additives

被引：117

作者：

Rudolph, J ^{[1
]}

Hermanns, N ^{[1
]}

Bolm, C ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 11期

关键词：

D O I：

10.1021/jo0495079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Small amounts of simple methoxy poly(ethylene glycol)s (MPEGs) have a beneficial effect on catalyzed asymmetric aryl and alkyl transfer reactions onto aldehydes. The enantiomeric excesses of the products are improved, and this "MPEG effect" allows a reduction of the catalyst loading by a factor of 10.

引用

页码：3997 / 4000

页数：4

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