Asymmetric synthesis of β-hydroxy-β-trifluoromethylated ketones via in situ generation of trifluoroacetaldehyde and its asymmetric carbon-carbon bond formation reaction with chiral imines in aqueous media

被引：7

作者：

Funabiki, Kazumasa ^{[1
]}

Hasegawa, Kazutoshi ^{[1
]}

Murase, Yoshihiro ^{[1
]}

Nagaya, Hideyuki ^{[1
]}

Matsui, Masaki ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, Gifu 5011193, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2006年 / 127卷 / 4-5期

关键词：

fluorine and compounds; asymmetric synthesis;

D O I：

10.1016/j.jfluchem.2005.12.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric synthesis of beta-hydroxy-beta-trifluoromethylated ketones via in situ generation of trifluoroacetaldehyde from its hemiacetal as well as the simultaneous asymmetric carbon-carbon bond formation reaction in aqueous media is described. (C) 2006 Elsevier B.V. All rights reserved.

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收藏

页码：545 / 547

页数：3

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