[5C+1S] annulation: A facile and efficient synthetic route toward functionalized 2,3-dihydrothiopyran-4-ones

被引：64

作者：

Bi, XH ^{[1
]}

Dong, DW ^{[1
]}

Li, Y ^{[1
]}

Liu, Q ^{[1
]}

Zhang, Q ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 26期

关键词：

D O I：

10.1021/jo052032g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient synthetic route toward highly substituted 2,3-dihydrothiopyran-4-ones 2 has been developed via a formal [5C + 1S] annulation of readily available alpha-alkenoyl ketene-(S,S)-acetals 1 with sodium sulfide nonahydrated salt (Na(2)S(.)9H(2)O) and utilized in the synthesis of 2-(4-chlorophenyl)-6-(morpholin-4-yl)-4H-thiopyran-4-one 51, an inhibitor of DNA-dependent protein kinase (DNA-PK).

引用

页码：10886 / 10889

页数：4

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