共 48 条
The p110γ isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
被引:41
作者:

Thomas, Molly S.
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Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA

Mitchell, Jason S.
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Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA

DeNucci, Christopher C.
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Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA

Martin, Amanda L.
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Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA

Shimizu, Yoji
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Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA
机构:
[1] Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol,Canc Ctr, Minneapolis, MN 55455 USA
关键词:
inflammation;
chemokines;
leukocyte;
activation;
trafficking;
D O I:
10.1189/jlb.0807561
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110 gamma isoform of PI-3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110 gamma does not regulate antigen- dependent CD4 T cell activation and proliferation, it plays a crucial role in regulating CD4 effector T cell migration. Nai r ve p110 gamma(-/-) CD4 lymphocytes are phenotypically identical to their wildtype ( WT) counterparts and do not exhibit any defects in TCR- mediated calcium mobilization or Erk activation. In addition, p110 gamma- deficient CD4 OT. II T cells become activated and proliferate comparably with WT cells in response to antigen in vivo. Interestingly, however, antigen- experienced, p110 gamma- deficient CD4 OT. II lymphocytes exhibit dramatic defects in their ability to traffic to peripheral inflammatory sites in vivo. Although antigen- activated, p110 gamma-deficient CD4 T cells express P- selectin ligand, beta 2 integrin, beta 1 integrin, CCR4, CXCR5, and CCR7 comparably with WT cells, they exhibit impaired Factin polarization and migration in response to stimulation ex vivo with the CCR4 ligand CCL22. These findings suggest that p110 gamma regulates the migration of antigen- experienced effector CD4 T lymphocytes into inflammatory sites during adaptive immune responses in vivo.
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页码:814 / 823
页数:10
相关论文
共 48 条
[1]
Phosphoinositide 3-kinase γ participates in T cell receptor-induced T cell activation
[J].
Alcázar, Isabela
;
Marqués, Miriam
;
Kumar, Amit
;
Hirsch, Emilio
;
Wymann, Matthias
;
Carrera, Ana C.
;
Barber, Domingo F.
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2007, 204 (12)
:2977-2987

Alcázar, Isabela
论文数: 0 引用数: 0
h-index: 0
机构: Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain

Marqués, Miriam
论文数: 0 引用数: 0
h-index: 0
机构: Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain

Kumar, Amit
论文数: 0 引用数: 0
h-index: 0
机构: Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain

Hirsch, Emilio
论文数: 0 引用数: 0
h-index: 0
机构: Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain

论文数: 引用数:
h-index:
机构:

Carrera, Ana C.
论文数: 0 引用数: 0
h-index: 0
机构: Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain

Barber, Domingo F.
论文数: 0 引用数: 0
h-index: 0
机构:
Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain Consejo Sup Invest Cien, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain
[2]
Isoform-specific functions of phosphoinositide 3-kinases:: p110δ but not p110γ promotes optimal allergic responses in vivo
[J].
Ali, Khaled
;
Camps, Montserrat
;
Pearce, Wayne P.
;
Ji, Hong
;
Rueckle, Thomas
;
Kuehn, Nicolas
;
Pasquali, Christian
;
Chabert, Christian
;
Rommel, Christian
;
Vanhaesebroeck, Bart
.
JOURNAL OF IMMUNOLOGY,
2008, 180 (04)
:2538-2544

Ali, Khaled
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Camps, Montserrat
论文数: 0 引用数: 0
h-index: 0
机构:
Merck Serono Int, Geneva Res Ctr, Geneva, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Pearce, Wayne P.
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Ji, Hong
论文数: 0 引用数: 0
h-index: 0
机构:
Merck Serono Int, Geneva Res Ctr, Geneva, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Rueckle, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Merck Serono Int, Geneva Res Ctr, Geneva, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Kuehn, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构:
Frimorfo, Fribourg, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Pasquali, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Merck Serono Int, Geneva Res Ctr, Geneva, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Chabert, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Merck Serono Int, Geneva Res Ctr, Geneva, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Rommel, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Merck Serono Int, Geneva Res Ctr, Geneva, Switzerland Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England

Vanhaesebroeck, Bart
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England Queen Mary Univ London, Sir John Vane Res Ctr, Inst Canc, Ctr Cell Signaling, London EC1M 6BQ, England
[3]
In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
[J].
Ansel, KM
;
McHeyzer-Williams, LJ
;
Ngo, VN
;
McHeyzer-Williams, MG
;
Cyster, JG
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1999, 190 (08)
:1123-1134

Ansel, KM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

McHeyzer-Williams, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

Ngo, VN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

McHeyzer-Williams, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

Cyster, JG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[4]
Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion
[J].
Barber, DF
;
Bartolomé, A
;
Hernandez, C
;
Flores, JM
;
Fernandez-Arias, C
;
Rodríguez-Borlado, L
;
Hirsch, E
;
Wymann, M
;
Balomenos, D
;
Carrera, AC
.
JOURNAL OF IMMUNOLOGY,
2006, 176 (01)
:589-593

Barber, DF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Bartolomé, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Hernandez, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Flores, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Fernandez-Arias, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Rodríguez-Borlado, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Hirsch, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

论文数: 引用数:
h-index:
机构:

Balomenos, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain

Carrera, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, E-28049 Madrid, Spain
[5]
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
[J].
Barber, DF
;
Bartolomé, A
;
Hernandez, C
;
Flores, JM
;
Redondo, C
;
Fernandez-Arias, C
;
Camps, M
;
Ruckle, T
;
Schwarz, MK
;
Rodríguez, S
;
Martinez-A, C
;
Balomenos, D
;
Rommel, C
;
Carrera, AC
.
NATURE MEDICINE,
2005, 11 (09)
:933-935

Barber, DF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Bartolomé, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Hernandez, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Flores, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Redondo, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Fernandez-Arias, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Camps, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Ruckle, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Schwarz, MK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Rodríguez, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Martinez-A, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Balomenos, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Rommel, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

Carrera, AC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain Univ Autonoma Madrid, Dept Immunol & Oncol, CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain
[6]
Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
[J].
Brock, C
;
Schaefer, M
;
Reusch, HP
;
Czupalla, C
;
Michalke, M
;
Spicher, K
;
Schultz, G
;
Nürnberg, B
.
JOURNAL OF CELL BIOLOGY,
2003, 160 (01)
:89-99

Brock, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Schaefer, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Reusch, HP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Czupalla, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Michalke, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Spicher, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Schultz, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany

Nürnberg, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dusseldorf Klinikum, Inst Physiol Chem 2, D-40225 Dusseldorf, Germany
[7]
Targeting T cell responses by selective chemokine receptor expression
[J].
Campbell, DJ
;
Debes, GF
;
Johnston, B
;
Wilson, E
;
Butcher, EC
.
SEMINARS IN IMMUNOLOGY,
2003, 15 (05)
:277-286

Campbell, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Debes, GF
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Johnston, B
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Wilson, E
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Butcher, EC
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA
[8]
Rapid acquisition of tissue-specific homing phenotypes by CD4+ T cells activated in cutaneous or mucosal lmphoid tissues
[J].
Campbell, DJ
;
Butcher, EC
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2002, 195 (01)
:135-141

Campbell, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Butcher, EC
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA
[9]
Cutting edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions
[J].
Campbell, James J.
;
O'Connell, Daniel J.
;
Wurbel, Marc-Andre
.
JOURNAL OF IMMUNOLOGY,
2007, 178 (06)
:3358-3362

Campbell, James J.
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA

O'Connell, Daniel J.
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA

Wurbel, Marc-Andre
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA
[10]
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
[J].
Campbell, JJ
;
Haraldsen, G
;
Pan, J
;
Rottman, J
;
Qin, S
;
Ponath, P
;
Andrew, DP
;
Warnke, R
;
Ruffing, N
;
Kassam, N
;
Wu, L
;
Butcher, EC
.
NATURE,
1999, 400 (6746)
:776-780

Campbell, JJ
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Haraldsen, G
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Pan, J
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Rottman, J
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Qin, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Ponath, P
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Andrew, DP
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Warnke, R
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Ruffing, N
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Kassam, N
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Wu, L
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

Butcher, EC
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA