QSAR studies on some antimalarial sulfonamides

被引：56

作者：

Agrawal, VK

Srivastava, R

Khadikar, PV ^{[1
]}

机构：

[1] Laxmi Pest & Fumigat Pvt Ltd, Div Res, Indore 452007, India

[2] APS Univ, Dept Chem, Rewa 486003, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0968-0896(01)00241-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimalarial activity of a series of sulfonamide derivatives (2,4-diamino-6-quinazoline sulfonamides) was modeled topologically using Wiener (W)-, and Szeged (Sz)-indices. The regression analysis of the data has shown that better results are obtained in multiparametric regressions upon introduction of indicator parameters. Predicting ability of the models was tested by r(cv)(2) values. It was observed that models based on W index gave slightly better results than those in which Sz is involved. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3287 / 3293

页数：7

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