Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians

被引：20

作者：

Kovacs, P ^{[1
]}

Yang, XL ^{[1
]}

Permana, PA ^{[1
]}

Bogardus, C ^{[1
]}

Baier, LJ ^{[1
]}

机构：

[1] NIDDK, Clin Diabet & Nutr Sect, NIH, Phoenix Epidemiol & Clin Res Branch, Phoenix, AZ 85016 USA

来源：

DIABETES | 2002年 / 51卷 / 05期

关键词：

D O I：

10.2337/diabetes.51.5.1618

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ORP150 gene that encodes the human oxygen-regulated protein (150 kDa) maps to chromosome 11q23, a region previously reported to be linked to type 2 diabetes and obesity in Pima Indians. This gene was also found to be differentially expressed in global gene expression studies comparing muscle mRNA from insulin-resistant versus insulin-sensitive subjects. Therefore, ORP150 was analyzed as a candidate gene for susceptibility to diabetes. Twelve variants were identified, and three unique representative polymorphisms were genotyped in 1,338 Pima Indians. None of these polymorphisms were associated with diabetes, but two polymorphisms were significantly associated with measures insulin resistance. These data indicate that ORP150 has a role in insulin action but does not have a major role in determining susceptibility to type 2 diabetes in Pima Indians.

引用

页码：1618 / 1621

页数：4

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