IL1HY1:: A novel interleukin-1 receptor antagonist gene

被引：80

作者：

Mulero, JJ ^{[1
]}

Pace, AM ^{[1
]}

Nelken, ST ^{[1
]}

Loeb, DB ^{[1
]}

Correa, TR ^{[1
]}

Drmanac, R ^{[1
]}

Ford, JE ^{[1
]}

机构：

[1] Hyseq Inc, Immunol Grp, Funct Genom Dept, Sunnyvale, CA 94086 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 263卷 / 03期

关键词：

IL-1ra; IL-1; inflammation; LPS; THP-1;

D O I：

10.1006/bbrc.1999.1440

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide variety of physiological and cellular events. We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%. The gene was mapped to the long arm of chromosome 2, in close proximity to the IL-1 locus. IL1HY1 message is tightly regulated being most predominantly expressed in the skin, but also detected in the spleen, brain leukocyte, and macrophage cell types. Furthermore, the message can be induced in THP-1 cells by phorbol ester (PIMA) and lipopolysaccharide (LPS)treatment. (C) 1999 Academic Press.

引用

页码：702 / 706

页数：5

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