Sex chromosomes and genetic association studies

被引：46

作者：

Clayton, David G. ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome Trust Juvenile Diabet Res Fdn, Diabet & Inflammat Lab, Dept Med Genet,Cambridge Inst Med Res,Addenbrooke, Cambridge CB2 0XY, England

来源：

GENOME MEDICINE | 2009年 / 1卷

基金：

英国惠康基金;

关键词：

PARENTAL-GENOTYPE RECONSTRUCTION; TRANSMISSION/DISEQUILIBRIUM TEST; TESTS; DISEQUILIBRIUM; LINKAGE; MARKERS;

D O I：

10.1186/gm110

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex population studies, and as a result of X inactivation. This paper reviews recent developments in approaching these problems.

引用

页数：7

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