Manipulating angiogenesis against vascular disease

被引：19

作者：

Isner, JM ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Boston, MA 02111 USA

来源：

HOSPITAL PRACTICE | 1999年 / 34卷 / 06期

关键词：

D O I：

10.3810/hp.1999.06.147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gene therapy to stimulate the growth of new blood vessels is proving to be an effective way of bypassing occluded arteries and reestablishing blood flow to ischemic tissues. It could eventually replace surgical revascularization and angioplasty, which are not only more invasive but also plagued with restenosis, problems limiting long-term. management of coronary artery and peripheral vascular disease.

引用

收藏

页码：69 / +

页数：11

相关论文

共 8 条

[1] LOCAL-DELIVERY OF VASCULAR ENDOTHELIAL GROWTH-FACTOR ACCELERATES REENDOTHELIALIZATION AND ATTENUATES INTIMAL HYPERPLASIA IN BALLOON-INJURED RAT CAROTID-ARTERY [J].

ASAHARA, T ;

BAUTERS, C ;

PASTORE, C ;

KEARNEY, M ;

ROSSOW, S ;

BUNTING, S ;

FERRARA, N ;

SYMES, JF ;

ISNER, JM .

CIRCULATION, 1995, 91 (11) :2793-2801

[2] Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia [J].

Baumgartner, I ;

Pieczek, A ;

Manor, O ;

Blair, R ;

Kearney, M ;

Walsh, K ;

Isner, JM .

CIRCULATION, 1998, 97 (12) :1114-1123

[3] Arterial gene transfer of naked DNA for therapeutic angiogenesis: early clinical results [J].

Isner, JM .

ADVANCED DRUG DELIVERY REVIEWS, 1998, 30 (1-3) :185-197

[4] Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results [J].

Isner, JM ;

Baumgartner, I ;

Rauh, G ;

Schainfeld, R ;

Blair, R ;

Manor, O ;

Razvi, S ;

Symes, JF .

JOURNAL OF VASCULAR SURGERY, 1998, 28 (06) :964-973

[5]

ISNER JM, 1998, COMPREHENSIVE CARDIO, P2973

[6]

ISNER JM, 1998, FRONT BIOSCI, V3, P49

[7] Gene therapy for myocardial angiogenesis -: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia [J].

Losordo, DW ;

Vale, PR ;

Symes, JF ;

Dunnington, CH ;

Esakof, DD ;

Maysky, M ;

Ashare, AB ;

Lathi, K ;

Isner, JM .

CIRCULATION, 1998, 98 (25) :2800-2804

[8] Immunohistochemical localization of lysozyme in the prelarvae of tilapia, Oreochromis mossambicus [J].

Takemura, A .

FISH & SHELLFISH IMMUNOLOGY, 1996, 6 (01) :75-77