DNA damage, chromatin, and transcription: the trinity of aging

被引：41

作者：

Burgess, Rebecca C. ^{[1
]}

Misteli, Tom ^{[1
]}

Oberdoerffer, Philipp ^{[2
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] NCI, NIH, Frederick, MD 21701 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 06期

关键词：

DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; GENE-EXPRESSION; REPAIR; ATM; HETEROCHROMATIN; UBIQUITIN; SIRT1; MAINTENANCE; STABILITY;

D O I：

10.1016/j.ceb.2012.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging brings about numerous cellular defects. Amongst the most prominent are elevated levels of persistent DNA damage, changes to chromatin structure and epigenetic modifications, and alterations of global transcription programs. These are not independent events and recent work begins to shed light on the intricate interplay between these aging-related defects.

引用

收藏

页码：724 / 730

页数：7

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