UCP1, UCP2 and UCP3: Are they true uncouplers of respiration?

被引：12

作者：

Bouillaud, F ^{[1
]}

机构：

[1] CNRS, CEREMOD, F-92190 Meudon, France

来源：

INTERNATIONAL JOURNAL OF OBESITY | 1999年 / 23卷 / Suppl 6期

关键词：

mitochondria; proton leak; yeast; Saccharomyces cerevisiae;

D O I：

10.1038/sj.ijo.0800938

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The thermogenesis in brown adipose tissue (BAT) is due to the activity of a mitochondrial uncoupling protein (UCP1). This protein allows the protons pumped by the respiratory chain to re-enter the matrix without ATP synthesis. Therefore respiration is dramatically increased and produces only heat. The discovery of genes showing strong similarities with the UCP1 gene and expressed in other tissues raised the possibility that these proteins participate in the proton leak observed in mitochondria, and therefore participate in the regulation of energy expenditure. The recombinant expression of UCP1. UCP2 and UCP3 in yeast allows the comparison of the coupling state of yeast mitochondria in the presence or absence of these proteins.

引用

收藏

页码：S19 / S23

页数：5

相关论文

共 30 条

[1] CYSTEINE RESIDUES ARE NOT ESSENTIAL FOR UNCOUPLING PROTEIN FUNCTION [J].

ARECHAGA, I ;

RAIMBAULT, S ;

PRIETO, S ;

LEVIMEYRUEIS, C ;

ZARAGOZA, P ;

MIROUX, B ;

RICQUIER, D ;

BOUILLAUD, F ;

RIAL, E .

BIOCHEMICAL JOURNAL, 1993, 296 :693-700

[2] The uncoupling proteins, a review [J].

Boss, O ;

Muzzin, P ;

Giacobino, JP .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 139 (01) :1-9

[3] Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold [J].

Boss, O ;

Samec, S ;

Dulloo, A ;

Seydoux, J ;

Muzzin, P ;

Giacobino, JP .

FEBS LETTERS, 1997, 412 (01) :111-114

[4] Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression [J].

Boss, O ;

Samec, S ;

PaoloniGiacobino, A ;

Rossier, C ;

Dulloo, A ;

Seydoux, J ;

Muzzin, P ;

Giacobino, JP .

FEBS LETTERS, 1997, 408 (01) :39-42

[5] Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature [J].

Boss, O ;

Samec, S ;

Kühne, F ;

Bijlenga, P ;

Assimacopoulos-Jeannet, F ;

Seydoux, J ;

Giacobino, JP ;

Muzzin, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) :5-8

[6] Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans [J].

Bouchard, C ;

Perusse, L ;

Chagnon, YC ;

Warden, C ;

Ricquier, D .

HUMAN MOLECULAR GENETICS, 1997, 6 (11) :1887-1889

[7]

BOUILLAUD F, 1992, MOL BIOL EVOL, V9, P970

[8] STABLE EXPRESSION OF FUNCTIONAL MITOCHONDRIAL UNCOUPLING PROTEIN IN CHINESE HAMSTER OVARY CELLS [J].

CASTEILLA, L ;

BLONDEL, O ;

KLAUS, S ;

RAIMBAULT, S ;

DIOLEZ, P ;

MOREAU, F ;

BOUILLAUD, F ;

RICQUIER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5124-5128

[9] Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [J].

Enerback, S ;

Jacobsson, A ;

Simpson, EM ;

Guerra, C ;

Yamashita, H ;

Harper, ME ;

Kozak, LP .

NATURE, 1997, 387 (6628) :90-94

[10] Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia [J].

Fleury, C ;

Neverova, M ;

Collins, S ;

Raimbault, S ;

Champigny, O ;

LeviMeyrueis, C ;

Bouillaud, F ;

Seldin, MF ;

Surwit, RS ;

Ricquier, D ;

Warden, CH .

NATURE GENETICS, 1997, 15 (03) :269-272