The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34

被引：23

作者：

Berger, J

Kurahashi, H

Takihara, Y

Shimada, K

Brock, HW

Randazzo, F

机构：

[1] Chiron Corp, Emeryville, CA 94608 USA

[2] Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z4, Canada

[3] Osaka Univ, Biomed Res Ctr, Dept Med Genet, Div Clin Genet, Osaka 5650871, Japan

[4] Osaka Univ, Microbial Dis Res Inst, Div Mol Biomed, Dept Med Genet, Osaka 5650871, Japan

来源：

GENE | 1999年 / 237卷 / 01期

基金：

加拿大自然科学与工程研究理事会; 英国医学研究理事会;

关键词：

homeotic; Mbt domain; polycomb group; SPM domain;

D O I：

10.1016/S0378-1119(99)00285-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two 1(3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：185 / 191

页数：7

共 29 条

[1] MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex
Alkema, MJ
Jacobs, J
Voncken, JW
Jenkins, NA
Copeland, NG
Satijn, DPE
Otte, AP
Berns, A
vanLohuizen, M
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (05) : 993 - 1003
[2] Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex
Alkema, MJ
Bronk, M
Verhoeven, E
Otte, A
vantVeer, LT
Berns, A
vanLohuizen, M
[J]. GENES & DEVELOPMENT, 1997, 11 (02) : 226 - 240
[3] CLONAL KARYOTYPIC ABNORMALITIES IN COLORECTAL ADENOMAS - CLUES TO THE EARLY GENETIC EVENTS IN THE ADENOMA-CARCINOMA SEQUENCE
BOMME, L
BARDI, G
PANDIS, N
FENGER, C
KRONBORG, O
HEIM, S
[J]. GENES CHROMOSOMES & CANCER, 1994, 10 (03) : 190 - 196
[4] Bornemann D, 1996, DEVELOPMENT, V122, P1621
[5] Bornemann D, 1998, GENETICS, V150, P675
[6] Deletion mapping on chromosome 1p in well-differentiated gastric cancer
Ezaki, T
Yanagisawa, A
Ohta, K
Aiso, S
Watanabe, M
Hibi, T
Kato, Y
Nakajima, T
Ariyama, T
Inazawa, J
Nakamura, Y
Horii, A
[J]. BRITISH JOURNAL OF CANCER, 1996, 73 (04) : 424 - 428
[7] POLYCOMB AND POLYHOMEOTIC ARE CONSTITUENTS OF A MULTIMERIC PROTEIN COMPLEX IN CHROMATIN OF DROSOPHILA-MELANOGASTER
FRANKE, A
DECAMILLIS, M
ZINK, D
CHENG, NS
BROCK, HW
PARO, R
[J]. EMBO JOURNAL, 1992, 11 (08) : 2941 - 2950
[8] Functions of mammalian Polycomb group and trithorax group related genes
Gould, A
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (04) : 488 - 494
[9] RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian polycomb group complexes
Hashimoto, N
Brock, HW
Nomura, M
Kyba, M
Hodgson, J
Fujita, Y
Takihara, Y
Shimada, K
Higashinakagawa, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 245 (02) : 356 - 365
[10] Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene
Hobert, O
Sures, I
Ciossek, T
Fuchs, M
Ullrich, A
[J]. MECHANISMS OF DEVELOPMENT, 1996, 55 (02) : 171 - 184

← 1 2 3 →