p53 expression is of independent predictive value in lymph node-negative breast carcinoma

被引:19
作者
Fresno, M
Molina, R
delRio, MJP
Alvarez, S
DiazIglesias, JM
Garcia, I
Herrero, A
机构
[1] Department of Pathology, Covadonga University Hospital, University of Oviedo, 33006 Oviedo, Celestino Villamil S/N
关键词
p53; immunohistochemistry; oncoprotein; breast carcinoma;
D O I
10.1016/S0959-8049(97)00096-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study was to evaluate p53 expression, determined by immunohistochemistry, in 151 infiltrating ductal breast carcinomas with negative axillary lymph nodes, and to determine whether p53 can be considered as an independent prognostic value for overall and disease-free survival. A monoclonal antibody (DO-7) that reacts with an epitope on the N terminal portion of the human protein p53 was used to detect p53 in paraffin-embedded sections, utilising a standard avidin-biotin-peroxidase complex (ABC) technique with a microwave oven antigen retrieval. Overexpression of p53 (more than 50% of stained cells) was found in 45 cases (30%). Forty-five cases were negative and occasionally or moderately stained cells were present in 61 cases. p53 protein overexpression was significantly associated with high histological grade and tumour necrosis, high MIB-1 value (MIB-1>30%) and negative oestrogen receptor status. Univariate analysis (log-rank) showed a shorter overall survival (P=0.003) in patients with high tumour p53 positivity. This statistical significance was also seen on multivariate analysis (Cox's logistic regression, P=0.004). p53 protein overexpression is an independent prognostic marker in node-negative breast carcinoma for overall survival and should be used with other prognostic factors. (C) 1997 Published by Elsevier Science Ltd.
引用
收藏
页码:1268 / 1274
页数:7
相关论文
共 44 条
[1]   ASSOCIATION OF P53 PROTEIN EXPRESSION WITH TUMOR-CELL PROLIFERATION RATE AND CLINICAL OUTCOME IN NODE-NEGATIVE BREAST-CANCER [J].
ALLRED, DC ;
CLARK, GM ;
ELLEDGE, R ;
FUQUA, SAW ;
BROWN, RW ;
CHAMNESS, GC ;
OSBORNE, CK ;
MCGUIRE, WL .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (03) :200-206
[2]   SUPPRESSION OF HUMAN COLORECTAL-CARCINOMA CELL-GROWTH BY WILD-TYPE-P53 [J].
BAKER, SJ ;
MARKOWITZ, S ;
FEARON, ER ;
WILLSON, JKV ;
VOGELSTEIN, B .
SCIENCE, 1990, 249 (4971) :912-915
[3]   TUMOR SUPPRESSOR GENE-PRODUCTS, PROLIFERATION, AND DIFFERENTIATION MARKERS IN LUNG NEUROENDOCRINE NEOPLASMS [J].
BARBARESCHI, M ;
GIRLANDO, S ;
MAURI, FA ;
ARRIGONI, G ;
LAURINO, L ;
DALLAPALMA, P ;
DOGLIONI, C .
JOURNAL OF PATHOLOGY, 1992, 166 (04) :343-350
[4]   P53 AND C-ERBB-2 PROTEIN EXPRESSION IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY INCLUDING CORRELATIONS WITH RECEPTOR STATUS, PROLIFERATION MARKERS, AND CLINICAL STAGE IN HUMAN BREAST-CANCER [J].
BARBARESCHI, M ;
LEONARDI, E ;
MAURI, FA ;
SERIO, G ;
PALMA, PD .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1992, 98 (04) :408-418
[5]   IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN IN MAMMARY-CARCINOMA - AN IMPORTANT NEW INDEPENDENT INDICATOR OF PROGNOSIS [J].
BARNES, DM ;
DUBLIN, EA ;
FISHER, CJ ;
LEVISON, DA ;
MILLIS, RR .
HUMAN PATHOLOGY, 1993, 24 (05) :469-476
[6]   PATTERNS OF EXPRESSION OF THE P53 TUMOR SUPPRESSOR IN HUMAN BREAST TISSUES AND TUMORS INSITU AND INVITRO [J].
BARTEK, J ;
BARTKOVA, J ;
VOJTESEK, B ;
STASKOVA, Z ;
REJTHAR, A ;
KOVARIK, J ;
LANE, DP .
INTERNATIONAL JOURNAL OF CANCER, 1990, 46 (05) :839-844
[7]   P53 IMMUNOHISTOCHEMISTRY - A WORD OF CAUTION [J].
BATTIFORA, H .
HUMAN PATHOLOGY, 1994, 25 (05) :435-437
[8]   ABNORMAL P53 IMMUNOREACTIVITY AND PROGNOSIS IN NODE-NEGATIVE BREAST CARCINOMAS WITH LONG-TERM FOLLOW-UP [J].
BOSARI, S ;
LEE, AKC ;
VIALE, G ;
HEATLEY, GJ ;
COGGI, G .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1992, 421 (04) :291-295
[9]  
CAMPO E, 1991, CANCER RES, V51, P4436
[10]   P53 EXPRESSION IN BREAST-CANCER [J].
CATTORETTI, G ;
RILKE, F ;
ANDREOLA, S ;
DAMATO, L ;
DELIA, D .
INTERNATIONAL JOURNAL OF CANCER, 1988, 41 (02) :178-183