p53;
immunohistochemistry;
oncoprotein;
breast carcinoma;
D O I:
10.1016/S0959-8049(97)00096-8
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The aim of this study was to evaluate p53 expression, determined by immunohistochemistry, in 151 infiltrating ductal breast carcinomas with negative axillary lymph nodes, and to determine whether p53 can be considered as an independent prognostic value for overall and disease-free survival. A monoclonal antibody (DO-7) that reacts with an epitope on the N terminal portion of the human protein p53 was used to detect p53 in paraffin-embedded sections, utilising a standard avidin-biotin-peroxidase complex (ABC) technique with a microwave oven antigen retrieval. Overexpression of p53 (more than 50% of stained cells) was found in 45 cases (30%). Forty-five cases were negative and occasionally or moderately stained cells were present in 61 cases. p53 protein overexpression was significantly associated with high histological grade and tumour necrosis, high MIB-1 value (MIB-1>30%) and negative oestrogen receptor status. Univariate analysis (log-rank) showed a shorter overall survival (P=0.003) in patients with high tumour p53 positivity. This statistical significance was also seen on multivariate analysis (Cox's logistic regression, P=0.004). p53 protein overexpression is an independent prognostic marker in node-negative breast carcinoma for overall survival and should be used with other prognostic factors. (C) 1997 Published by Elsevier Science Ltd.
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
BARNES, DM
;
DUBLIN, EA
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
DUBLIN, EA
;
FISHER, CJ
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
FISHER, CJ
;
LEVISON, DA
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
LEVISON, DA
;
MILLIS, RR
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
BARTEK, J
;
BARTKOVA, J
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机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
BARTKOVA, J
;
VOJTESEK, B
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
VOJTESEK, B
;
STASKOVA, Z
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
STASKOVA, Z
;
REJTHAR, A
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h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
REJTHAR, A
;
KOVARIK, J
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h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
KOVARIK, J
;
LANE, DP
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
BARNES, DM
;
DUBLIN, EA
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
DUBLIN, EA
;
FISHER, CJ
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
FISHER, CJ
;
LEVISON, DA
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
LEVISON, DA
;
MILLIS, RR
论文数: 0引用数: 0
h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
BARTEK, J
;
BARTKOVA, J
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
BARTKOVA, J
;
VOJTESEK, B
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
VOJTESEK, B
;
STASKOVA, Z
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
STASKOVA, Z
;
REJTHAR, A
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
REJTHAR, A
;
KOVARIK, J
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND
KOVARIK, J
;
LANE, DP
论文数: 0引用数: 0
h-index: 0
机构:
IMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLANDIMPERIAL CANC RES FUND, CLARE HALL LABS, POTTERS BAR EN6 3LD, HERTS, ENGLAND