Sperm cell proteomics

被引：124

作者：

Oliva, Rafael ^{[1
,2
]}

de Mateo, Sara ^{[1
,2
]}

Estanyol, Josep Maria ^{[3
]}

机构：

[1] Univ Barcelona, Fac Med, Human Genet Res Grp, IDIBAPS, Barcelona 08036, Spain

[2] Hosp Clin Barcelona, Biochem & Mol Genet Serv, Barcelona, Spain

[3] Univ Barcelona, Fac Med, Unitat Prote, Serv Suport Recerca, Barcelona 08036, Spain

来源：

PROTEOMICS | 2009年 / 9卷 / 04期

关键词：

Epigenetic; Imprinting; Protamine; Proteome; Spermatozoa; IPG STRIP PREFRACTIONATION; TYROSINE KINASE-ACTIVITY; LC-MS/MS IDENTIFICATION; MALE GERM-CELLS; HUMAN SPERMATOZOA; MASS-SPECTROMETRY; MALE-INFERTILITY; HUMAN SPERMATOGENESIS; GEL-ELECTROPHORESIS; CHROMATIN-STRUCTURE;

D O I：

10.1002/pmic.200800588

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The spermatozoon is an accessible cell which can be easily purified and therefore it is particularly well suited for proteomic analysis. It is also an extremely differentiated cell with very marked genetic, cellular, functional and chromatin changes as compared to other cells, and has profound implications for fertility, embryo development and heredity. The recent developments in MS have boosted the potential for identification and study of the sperm proteins. Catalogues of hundreds to thousands of spermatozoan proteins in human and in model species are becoming available setting up the basis for subsequent research, diagnostic applications and the development of specific treatments. The present article reviews the available scientific publications dealing with the composition and function of the sperm cell using an MS proteomic approach.

引用

页码：1004 / 1017

页数：14

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