Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux

被引：12

作者：

Junyaprasert, VB

Soonthornchareonnon, N

Thongpraditchote, S

Murakami, T

Takano, M

机构：

[1] Mahidol Univ, Fac Pharm, Dept Pharm, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Pharm, Dept Pharmacognosy, Bangkok 10400, Thailand

[3] Mahidol Univ, Fac Pharm, Dept Physiol, Bangkok 10400, Thailand

[4] Hiroshima Univ, Grad Sch Biomed Sci, Program Pharmaceut Sci,Div Clin Pharmaceut Sci, Dept Pharmaceut & Therapeut,Minami Ku, Hiroshima 7348551, Japan

来源：

PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 01期

关键词：

P-glycoprotein; plant extract; inhibition; efflux; Caco-2; cells; rat ileum;

D O I：

10.1002/ptr.1785

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. L) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 1.23 (Rho-123) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：79 / 81

页数：3

共 12 条

[1]

Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder [J].