Anti-bacterial and cytotoxic properties of plasma sprayed silver-containing HA coatings

被引：167

作者：

Chen, Yikai ^{[1
]}

Zheng, Xuebin ^{[1
]}

Xie, Youtao ^{[1
]}

Ding, Chuanxian ^{[1
]}

Ruan, Hongjiang ^{[2
]}

Fan, Cunyi ^{[2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2008年 / 19卷 / 12期

关键词：

D O I：

10.1007/s10856-008-3529-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Silver-containing hydroxyapatite (HA) coatings have been prepared on titanium substrate by vacuum plasma spraying (VPS) method and anti-bacterial properties of the coatings were examined. Three types of bacteria stains, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, were employed in this test. The results showed that the silver-containing HA coatings exhibited significant anti-bacterial effects against the three bacteria with anti-bacterial ratios higher than 95%. The release of silver ions in the physiological environment ensured excellent anti-bacterial properties of the silver-containing HA coatings. International standard ISO 10993-12 was adopted for cytotoxicity evaluation using fibroblast cell line L929, and it was found that the cytotoxicity for the coatings ranked 0 that showed no cytotoxicity for the coatings. Hemolysis test was processed according to ASTM F 756 standard with anti-coagulated rabbit blood, and the hemolysis ratios of the coatings were below 0.4%, indicating of non-hemolysis for the coatings.

引用

页码：3603 / 3609

页数：7

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