Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex

被引：35

作者：

Marenco, S ^{[1
]}

Steele, SU ^{[1
]}

Egan, MF ^{[1
]}

Goldberg, TE ^{[1
]}

Straub, RE ^{[1
]}

Sharrief, AZ ^{[1
]}

Weinberger, DR ^{[1
]}

机构：

[1] NIMH, Marenco Genes & Cognit Program, Clin Brain Disorders Branch, Intramural Program,NIH, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2006年 / 163卷 / 04期

关键词：

D O I：

10.1176/appi.ajp.163.4.740

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism ( SNP) in the metabotropic glutamate receptor 3 ( GRM3) gene ( a putative risk factor for schizophrenia) on measures of N-acetylaspartate in healthy comparison subjects. Method: Fifty-four carefully screened healthy volunteers genotyped at SNP rs6465084 underwent magnetic resonance spectroscopic imaging ( MRSI) at 3 T and selected neuropsychological testing. Results: The A/A genotype group exhibited a significant reduction of N-acetylaspartate/ creatine levels in the right dorsolateral prefrontal cortex compared to the G carriers. A tendency in the same direction was seen in the left dorsolateral prefrontal cortex and in the white matter adjacent to the prefrontal cortex. Conclusions: These findings provide further evidence that GRM3 affects prefrontal function and that variation in GRM3, monitored by SNP rs6465084, affects GRM3 function.

引用

页码：740 / 742

页数：3

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