3D-biohybrid systems: applications in drug screening

被引：48

作者：

Reininger-Mack, A ^{[1
]}

Thielecke, H ^{[1
]}

Robitzki, AA ^{[1
]}

机构：

[1] Fraunhofer Inst Biomed Engn, FhG IBMT, Dept Biohybrid Syst, D-66386 St Ingbert, Germany

来源：

TRENDS IN BIOTECHNOLOGY | 2002年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(01)01880-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biotechnology demands powerful methods for the functional characterisation and monitoring of molecular alterations in tissues in response to various stimuli. Currently, cellular biosensors provide information about cell and tissue internal transduction pathways. In this article, recent biosensor systems are briefly described and the use of 3D tissue aggregates as recognition elements is discussed. An example of an innovative approach for drug testing using 3D heart muscle aggregates, as well as tumor models, positioned in capillary systems for electrical potential recording and impedance measurement is described. The effectiveness of drugs and therapies can be tested and monitored in a short time using such biohybrid sensors.

引用

页码：56 / 61

页数：6

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