Reduced levels of insulin-like growth factor-1 in patients with angina pectoris, positive exercise stress test, and angiographically normal epicardial coronary arteries

被引：36

作者：

Conti, E

Andreotti, F

Sestito, A

Riccardi, P

Menini, E

Crea, F

Maseri, A

Lanza, GA

机构：

[1] Catholic Univ, Inst Cardiol, Rome, Italy

[2] Catholic Univ, Inst Obstet & Gynaecol, Rome, Italy

[3] Catholic Univ, Hormones Lab, Rome, Italy

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 89卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(02)02250-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum insulin-like growth factor-1 (IGF-1) concentrations were found to be lower (p = 0.002) and insulin levels higher (p = 0.004) in patients with syndrome X than in healthy controls. There was an inverse correlation between insulin and IGF-1 blood levels (r = -0.54, p = 0.005), suggesting that the reduced IGF-1 levels may be involved in the impaired insulin sensitivity of patients with syndrome X.

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页码：973 / +

页数：5

相关论文

共 20 条

[1] INSULIN-RECEPTOR DOWN-REGULATION AND IMPAIRED ANTILIPOLYTIC ACTION OF INSULIN IN DIABETIC-PATIENTS AFTER PANCREAS/KIDNEY TRANSPLANTATION [J].

BODEN, G ;

CHEN, XH ;

RUIZ, J ;

HEIFETS, M ;

MORRIS, M ;

BADOSA, F .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (03) :657-663

[2] ESTIMATES OF INVIVO INSULIN ACTION IN MAN - COMPARISON OF INSULIN TOLERANCE-TESTS WITH EUGLYCEMIC AND HYPERGLYCEMIC GLUCOSE CLAMP STUDIES [J].

BONORA, E ;

MOGHETTI, P ;

ZANCANARO, C ;

CIGOLINI, M ;

QUERENA, M ;

CACCIATORI, V ;

CORGNATI, A ;

MUGGEO, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (02) :374-378

[3]

BOTKER HE, 1993, LANCET, V342, P136

[4] MICROVASCULAR ANGINA AS A CAUSE OF CHEST PAIN WITH ANGIOGRAPHICALLY NORMAL CORONARY-ARTERIES [J].

CANNON, RO ;

EPSTEIN, SE .

AMERICAN JOURNAL OF CARDIOLOGY, 1988, 61 (15) :1338-1343

[5] HYPERINSULINEMIA, CORONARY-ARTERY DISEASE AND SYNDROME-X [J].

CHAUHAN, A ;

FOOTE, J ;

PETCH, MC ;

SCHOFIELD, PM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 23 (02) :364-368

[6]

Chauhan A, 1997, EUR HEART J, V18, P60

[7] INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II - PEPTIDE, MESSENGER RIBONUCLEIC-ACID AND GENE STRUCTURES, SERUM, AND TISSUE CONCENTRATIONS [J].

DAUGHADAY, WH ;

ROTWEIN, P .

ENDOCRINE REVIEWS, 1989, 10 (01) :68-91

[8]

DEAN JD, 1991, LANCET, V337, P456

[9] Different effects of IGF-I on insulin-stimulated glucose uptake in adipose tissue and skeletal muscle [J].

Frick, F ;

Oscarsson, J ;

Vikman-Adolfsson, K ;

Ottosson, M ;

Yoshida, N ;

Edén, S .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 278 (04) :E729-E737

[10] INSULIN-LIKE GROWTH-FACTOR-I AND INSULIN HAVE NO DIFFERENTIAL-EFFECTS ON GLUCOSE-PRODUCTION AND UTILIZATION UNDER CONDITIONS OF HYPERGLYCEMIA [J].

GIACCA, A ;

FISHER, SJ ;

SHI, ZQ ;

GUPTA, R ;

LICKLEY, HLA ;

SKOTTNER, A ;

ANDERSON, GH ;

EFENDIC, S ;

VRANIC, M .

ENDOCRINOLOGY, 1994, 134 (05) :2251-2258