Plasma interleukin-18 levels in patients with psychiatric disorders

被引：60

作者：

Kokai, M

Kashiwamura, S

Okamura, H

Ohara, K

Morita, Y

机构：

[1] Hyogo Med Univ, Dept Neuropsychiat, Inst Adv Med Sci, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Med Univ, Host Def Lab, Inst Adv Med Sci, Nishinomiya, Hyogo 6638501, Japan

来源：

JOURNAL OF IMMUNOTHERAPY | 2002年 / 25卷

关键词：

plasma; interleukin-18; depression; anxiety; stress;

D O I：

10.1097/00002371-200203001-00011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There are an increasing number of reports on an association between the alteration of circulating cytokine levels and pathophysiology of psychiatric disorders. Plasma concentrations of interleukin (IL)-18 were measured in 13 nonmedicated patients with psychiatric disorders. There was a significant elevation of IL-18 levels in patients with major depression (n = 8) and panic disorder (n = 5), compared with normal controls. The mean IL-18 value of our psychiatric patients was comparable with that of various somatic disorders reported. We suggest that the elevation of plasma IL-18 levels reflects the increased production and release of IL-18 in the central nervous system under stressful settings. We propose that the measurement of IL-18 plasma levels may provide a useful index for the involvement of immune system in psychiatric disorders.

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收藏

页码：S68 / S71

页数：4

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