Quantitative trait loci for neuroticism: An allelic association study with the serotonin receptor (HTR2) and monoamine oxidase A (MAOA) genes

被引：4

作者：

Jorm, AF ^{[1
]}

Henderson, AS ^{[1
]}

Jacomb, PA ^{[1
]}

Croft, L ^{[1
]}

Easteal, S ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,CANBERRA,ACT 0200,AUSTRALIA

来源：

PERSONALITY AND INDIVIDUAL DIFFERENCES | 1997年 / 22卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0191-8869(96)00200-0

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Neuroticism is an important liability factor for the development of anxiety and depressive disorders. Genetic studies of these disorders might be more profitably focused on this liability trait than on the disorders themselves. Quantitative genetic studies have shown a heritability of similar to 0.42 for neuroticism. Advances in molecular genetics now make it possible to identify allelic variation at particular loci associated with such quantitative traits. Reported here are the results of an allelic association study of neuroticism with two candidate genes: the serotonin receptor (HTR2) and monoamine oxidase A (MAO A) genes. As a secondary issue, associations with extraversion were also investigated. Elderly subjects aged 70(+) participating in a longitudinal study were assessed for neuroticism and extraversion on the first wave of the study and DNA was collected on the second wave, 3.6 years later. Data on both neuroticism and genotype were available for 432 subjects. No associations were found between genotype and either personality trait, despite there being sufficient statistical power to detect small associations. (C) 1997 Elsevier Science Ltd.

引用

页码：287 / 290

页数：4

共 29 条

[1] NEUROTICISM AND EXTRAVERSION IN TURNERS SYNDROME [J].

BAEKGAARD, W ;

NYBORG, H ;

NIELSEN, J .

JOURNAL OF ABNORMAL PSYCHOLOGY, 1978, 87 (05) :583-586

[2] Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking [J].

Benjamin, J ;

Li, L ;

Patterson, C ;

Greenberg, BD ;

Murphy, DL ;

Hamer, DH .

NATURE GENETICS, 1996, 12 (01) :81-84

[3] ABNORMAL-BEHAVIOR ASSOCIATED WITH A POINT MUTATION IN THE STRUCTURAL GENE FOR MONOAMINE OXIDASE-A [J].

BRUNNER, HG ;

NELEN, M ;

BREAKEFIELD, XO ;

ROPERS, HH ;

VANOOST, BA .

SCIENCE, 1993, 262 (5133) :578-580

[4] AGGRESSIVE-BEHAVIOR AND ALTERED AMOUNTS OF BRAIN-SEROTONIN AND NOREPINEPHRINE IN MICE LACKING MAOA [J].

CASES, O ;

SEIF, I ;

GRIMSBY, J ;

GASPAR, P ;

CHEN, K ;

POURNIN, S ;

MULLER, U ;

AGUET, M ;

BABINET, C ;

SHIH, JC ;

DEMAEYER, E .

SCIENCE, 1995, 268 (5218) :1763-1766

[5] Mapping genes for human personality [J].

Cloninger, CR ;

Adolfsson, R ;

Svrakic, NM .

NATURE GENETICS, 1996, 12 (01) :3-4

[6]

CLONINGER CR, 1987, ARCH GEN PSYCHIAT, V44, P573

[7] Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking [J].

Ebstein, RP ;

Novick, O ;

Umansky, R ;

Priel, B ;

Osher, Y ;

Blaine, D ;

Bennett, ER ;

Nemanov, L ;

Katz, M ;

Belmaker, RH .

NATURE GENETICS, 1996, 12 (01) :78-80

[8] A REVISED VERSION OF THE PSYCHOTICISM SCALE [J].

EYSENCK, SBG ;

EYSENCK, HJ ;

BARRETT, P .

PERSONALITY AND INDIVIDUAL DIFFERENCES, 1985, 6 (01) :21-29

[9]

Goldberg D.P., 1992, Common Mental Disorders: a bio-social model

[10] AN ALTERNATIVE DESCRIPTION OF PERSONALITY - THE BIG-5 FACTOR STRUCTURE [J].

GOLDBERG, LR .

JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1990, 59 (06) :1216-1229

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