Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor β Signaling

被引：332

作者：

Petrocca, Fabio ^{[1
]}

Vecchione, Andrea ^{[1
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Human Canc Genet Program, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 20期

关键词：

D O I：

10.1158/0008-5472.CAN-08-1768

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inactivation of the transforming growth factor beta (TGF beta) tumor suppressor pathway is a main step in the development of a variety of human tumors. The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGF beta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. Genetic ablation of these microRNAs (miRNAs) reveals their physiologic role in the control of liver and central nervous system apoptosis, supporting the notion that miRNA-based homeostatic mechanisms can be usurped by cancer cells to resist TGF beta tumor suppression. [Cancer Res 2008;68(20):8191-4]

引用

页码：8191 / 8194

页数：4

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