Noninvasive Three-Dimensional Cardiac Activation Imaging From Body Surface Potential Maps: A Computational and Experimental Study on a Rabbit Model

被引:42
作者
Han, Chengzong [1 ]
Liu, Zhongming [1 ]
Zhang, Xin
Pogwizd, Steven [2 ]
He, Bin [1 ]
机构
[1] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA
[2] Univ Illinois, Dept Med, Chicago, IL 60612 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Activation imaging; cardiac electrical imaging; electrocardiography; intracardiac mapping; inverse problem; rabbit model;
D O I
10.1109/TMI.2008.929094
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Three-dimensional (3-D) cardiac activation imaging (3-DCAI) is a recently developed technique that aims at imaging the activation sequence throughout the the ventricular myocardium. 3-DCAI entails the modeling and estimation of the cardiac equivalent current density (ECD) distribution from which the activation time at any myocardial site is determined as the time point with the peak amplitude of local ECD estimates. In this paper, we report, for the first time, an in vivo validation study assessing the feasibility of 3-DCAI in comparison with the 3-D intracardiac mapping, for a group of four healthy rabbits undergoing the ventricular pacing from various locations. During the experiments, the body surface potentials and the intramural bipolar electrical recordings were simultaneously measured in a closed-chest condition. The ventricular activation sequence noninvasively imaged from the body surface measurements by using 3-DCAI was generally in agreement with that obtained from the invasive intramural recordings. The quantitative comparison between them showed a root mean square (rms) error of 7.42 +/- 0.61 ms, a relative error (RE) of 0.24 +/- 0.03, and a localization error (LE) of 5.47 +/- 1.57mm. The experimental results were also consistent with our computer simulations conducted in well-controlled and realistic conditions. The present study suggest that 3-DCAI can noninvasively capture some important features of ventricular excitation (e.g., the activation origin and the activation sequence), and has the potential of becoming a useful imaging tool aiding cardiovascular research and clinical diagnosis of cardiac diseases.
引用
收藏
页码:1622 / 1630
页数:9
相关论文
共 32 条
[1]   RELATING EPICARDIAL TO BODY-SURFACE POTENTIAL DISTRIBUTIONS BY MEANS OF TRANSFER-COEFFICIENTS BASED ON GEOMETRY MEASUREMENTS [J].
BARR, RC ;
RAMSEY, M ;
SPACH, MS .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1977, 24 (01) :1-11
[2]   INVERSE CALCULATION OF QRS-T EPICARDIAL POTENTIALS FROM BODY-SURFACE POTENTIAL DISTRIBUTIONS FOR NORMAL AND ECTOPIC BEATS IN INTACT DOG [J].
BARR, RC ;
SPACH, MS .
CIRCULATION RESEARCH, 1978, 42 (05) :661-675
[3]   A critical analysis of linear inverse solutions to the neuroelectromagnetic inverse problem [J].
de Peralta-Menendez, RG ;
Gonzalez-Andino, SL .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1998, 45 (04) :440-448
[4]   SPREAD OF ACTIVATION IN THE LEFT VENTRICULAR WALL OF THE DOG .2. ACTIVATION CONDITIONS AT THE EPICARDIAL SURFACE [J].
DURRER, D ;
VANDERTWEEL, LH .
AMERICAN HEART JOURNAL, 1954, 47 (02) :192-203
[5]   An improved method for estimating epicardial potentials from the body surface [J].
Greensite, F ;
Huiskamp, G .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1998, 45 (01) :98-104
[6]  
GREENSITE F, 2004, MODELING IMAGING BIO, P119
[7]   MOVING DIPOLE INVERSE ECG AND EEG SOLUTIONS [J].
GULRAJANI, RM ;
ROBERGE, FA ;
SAVARD, P .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1984, 31 (12) :903-910
[8]   THE DISCRETE PICARD CONDITION FOR DISCRETE ILL-POSED PROBLEMS [J].
HANSEN, PC .
BIT NUMERICAL MATHEMATICS, 1990, 30 (04) :658-672
[9]   Noninvasive imaging of cardiac transmembrane potentials within three-dimensional myocardium by means of a realistic geometry anisotropic heart model [J].
He, B ;
Li, GL ;
Zhang, X .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2003, 50 (10) :1190-1202
[10]   Noninvasive three-dimensional activation time imaging of ventricular excitation by means of a heart-excitation model [J].
He, B ;
Li, GL ;
Zhang, X .
PHYSICS IN MEDICINE AND BIOLOGY, 2002, 47 (22) :4063-4078