Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling

被引：37

作者：

Epling-Burnette, P. K. ^{[1
,2
,3
]}

Sokol, Lubomir ^{[4
]}

Chen, Xianhong ^{[1
,2
]}

Bai, Fanqi ^{[1
,2
]}

Zhou, Junmin ^{[1
,2
]}

Blaskovich, Michelle A. ^{[1
,2
]}

Zou, JianXiang ^{[1
,2
]}

Painter, Jeffrey S. ^{[1
,2
]}

Edwards, Todd D. ^{[5
]}

Moscinski, Lynn ^{[6
]}

Yoder, Jeffrey A. ^{[7
,8
]}

Djeu, Julie Y. ^{[1
,2
]}

Sebti, Said ^{[1
,2
]}

Loughran, Thomas P., Jr. ^{[9
]}

Wei, Sheng ^{[1
,2
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[2] Res Inst Immunol Program, Dept Interdisciplinary Oncol, Tampa, FL USA

[3] James A Haley Vet Adm Hosp, Tampa, FL USA

[4] Univ S Florida, Dept Interdisciplinary Oncol, Malignant Hematol Div, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[5] Stern Cardiovasc Ctr Wolf River, Germantown, TN USA

[6] Univ S Florida, Dept Interdisciplinary Oncol, Div Pathol, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[7] N Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC USA

[8] N Carolina State Univ, Coll Vet Med, Ctr Comparat Med & Translat Res, Raleigh, NC USA

[9] Penn State Univ, Penn State Canc Inst, Coll Med, Hershey, PA USA

来源：

BLOOD | 2008年 / 112卷 / 12期

关键词：

D O I：

10.1182/blood-2008-02-136382

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Large granular lymphocyte (LGL) leukemia is commonly associated with poor hematopoiesis. The first case of pulmonary artery hypertension (PAH) was observed in a 57-year-old woman with natural killer (NK)-LGL leukemia and transfusion-dependent anemia. Using a genetic approach, we demonstrated that killing of pulmonary endothelial cells by patient NK cells was mediated by dysregulated balance in activating and inhibitory NK-receptor signaling. Elevated pulmonary artery pressure and erythroid differentiation improved after disrupting the NK-receptor signaling pathway with 4 courses of a farnesyltransferase inhibitor, tipifarnib. Coincidental association between PAH and LGL leukemia suggest a causal relationship between the expanded lymphocyte population and these clinical manifestations. This trial is registered at www.ClinicalTrials.gov as NCI 6823. (Blood. 2008; 112: 4694-4698)

引用

页码：4694 / 4698

页数：5

共 25 条

[1]

Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].

Bauer, Stefan ;

Groh, Veronika ;

Wu, Jun ;

Steinle, Alexander ;

Phillips, Joseph H. ;

Lanier, Lewis L. ;

Spies, Thomas .

JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233

[2]

ITAMs versus ITIMs: striking a balance during cell regulation [J].

Billadeau, DD ;

Leibson, PJ .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (02) :161-168

[3]

ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL) [J].

Epling-Burnett, PK ;

Bai, FQ ;

Wei, S ;

Chaurasia, P ;

Painter, JS ;

Olashaw, N ;

Hamilton, A ;

Sebti, S ;

Djeu, JY ;

Loughran, TP .

ONCOGENE, 2004, 23 (57) :9220-9229

[4]

Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes [J].

Epling-Burnette, PK ;

Painter, JS ;

Chaurasia, P ;

Bai, FQ ;

Wei, S ;

Djeu, JY ;

Loughran, TP .

BLOOD, 2004, 103 (09) :3431-3439

[5]

NK cells in innate immunity [J].

Hamerman, JA ;

Ogasawara, K ;

Lanier, LL .

CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (01) :29-35

[6]

HARRIS NL, 1994, BLOOD, V84, P1361

[7]

Killer immunoglobulin-like receptor genotype in immune-mediated bone marrow failure syndromes [J].

Howe, EC ;

Wlodarski, M ;

Ball, EJ ;

Rybicki, L ;

Madejewski, JP .

EXPERIMENTAL HEMATOLOGY, 2005, 33 (11) :1357-1362

[8]

Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation [J].

Kersh, EN ;

Kersh, GJ ;

Allen, PM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) :1627-1636

[9]

Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igβ cytoplasmic tail [J].

Kraus, M ;

Pao, LI ;

Reichlin, A ;

Hu, Y ;

Canono, B ;

Cambier, JC ;

Nussenzweig, MC ;

Rajewsky, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :455-469

[10]

Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice [J].

Lamy, T ;

Bauer, FA ;

Liu, JH ;

Li, YX ;

Pillemer, E ;

Shahidi, H ;

Gregory, SA ;

Zambello, R ;

Marcolongo, R ;

Semenzato, G ;

Loughran, TP .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 108 (04) :717-723

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