Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

被引：312

作者：

Krashes, Michael J. ^{[1
]}

Shah, Bhavik P. ^{[1
]}

Koda, Shuichi ^{[1
,2
]}

Lowell, Bradford B. ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol,Dept Med, Boston, MA 02215 USA

[2] Asubio Pharmaceut, Kobe, Hyogo 6500047, Japan

来源：

CELL METABOLISM | 2013年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

AGOUTI-RELATED PEPTIDE; NEUROPEPTIDE-Y; POMC NEURONS; MICE; LEPTIN; RECEPTORS; BEHAVIOR; CIRCUIT;

D O I：

10.1016/j.cmet.2013.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA agonist results in the marked escalation of food consumption with temporal variance. Given the orexigenic capability of all three of these neuroactive substances in conjunction with their coexpression in AgRP neurons, we looked to unravel their relative temporal role in driving food intake. After the acute stimulation of AgRP neurons with DREADD technology, we found that either GABA or NPY is required for the rapid stimulation of feeding, and the neuropeptide AgRP, through action on MC4 receptors, is sufficient to induce feeding over a delayed yet prolonged period. These studies help to elucidate the neurochemical mechanisms of AgRP neurons in controlling temporally distinct phases of eating.

引用

页码：588 / 595

页数：8

共 28 条

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Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors [J].