Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506

被引：30

作者：

Chan, MA ^{[1
]}

Kohlmeier, JE ^{[1
]}

Branden, M ^{[1
]}

Jung, M ^{[1
]}

Benedict, SH ^{[1
]}

机构：

[1] Univ Kansas, Dept Microbiol, Lawrence, KS 66045 USA

来源：

PHYTOTHERAPY RESEARCH | 1999年 / 13卷 / 06期

关键词：

triptolide; FK506; IL-2; IFN gamma; T-cell proliferation;

D O I：

10.1002/(SICI)1099-1573(199909)13:6<464::AID-PTR483>3.3.CO;2-W

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The Chinese traditional herb Tripterygium wilfordii Book, F (TWHF) has been reported to be effective in the treatment of a variety of autoimmune disorders. The major active component of this herb is triptolide and most of the efficacy of this herb immunosuppression is attributed to triptolide. FK506 is also a potent immunosuppressive agent and is currently being used clinically. The present studies compare the effectiveness of triptolide and FK506 to suppress certain human T cell functions, Specifically human T cell proliferation, IL-2 and IFN gamma were compared. The results show that, overall, triptolide is more effective at inhibiting T cell proliferation and IFN gamma production than FK506 and the two compounds inhibit IL-2 production in an equivalent manner. Copyright (C) 1999 John Wiley gr Sons, Ltd.

引用

页码：464 / 467

页数：4

共 10 条

[1]

Inhibition of murine chronic graft-versus-host disease by the chloroform extract of Tripterygium wilfordii Hook f [J].