Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS

被引：38

作者：

Strauss, JF

Wood, JR

Christenson, LK

McAllister, JM

机构：

[1] Univ Penn, Med Ctr, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA

[2] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2002年 / 186卷 / 02期

关键词：

polycystic ovary syndrome; androgen biosynthesis; suppression subtractive hybridization; chromatin immunoprecipitation;

D O I：

10.1016/S0303-7207(01)00662-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：183 / 188

页数：6

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