Anti-inflammatory action of Cudrania tricuspidata on spleen cell and T lymphocyte proliferation

被引：25

作者：

Chang, Sung Ho ^{[1
,2
,3
,4
]}

Jung, Eun Jung ^{[1
,2
,3
]}

Lim, Dong Gyun ^{[1
,2
,3
]}

Oyungerel, Baatartsogt ^{[4
]}

Lim, Kwan Il ^{[6
]}

Her, Erk ^{[5
]}

Choi, Wahn Soo ^{[5
]}

Jun, Myung Ha ^{[5
]}

Choi, Kang Duk ^{[4
]}

Han, Duck Jong ^{[1
,2
,3
]}

Kim, Song Cheol ^{[1
,2
,3
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Surg, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul 138736, South Korea

[3] Asan Med Ctr, Seoul 138736, South Korea

[4] Hankyong Natl Univ, Gyeong Gi Reg Res Ctr, Ansung City 456749, Gyeonggi Do, South Korea

[5] Konkuk Univ, Coll Med, Dept Immunol, Chungju 380701, South Korea

[6] Taepyung Oriental Med Clin, Seoul 236423, South Korea

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 2008年 / 60卷 / 09期

关键词：

D O I：

10.1211/jpp.60.9.0015

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

This study examined whether an extract of Cudrania tricuspidata shows anti-proliferative effects in anti-CD3/CD28-mediated spleen and CD4(+)CD25(-) T cells and decreases the production of the proinflammatory cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) in anti-CD3/CD28-mediated CD4(+)CD25(-) T cells. The proliferation of anti-CD3/CD28-mediated spleen cells and CD4(+)CD25(-) T cells was effectively suppressed by C. tricuspidata. This extract, however, did not show cytotoxicity in spleen cells under conditions where the antigen was not stimulated using CCK-8 analysis. C. tricuspidata also decreased the production of the pro-inflammatory cytokines IL-2 and IFN-gamma by selective inhibition of this extract on proliferating cells in anti-CD3/CD28-mediated CD4(+)CD25(-) T cells. These results suggest that C. tricuspidata may be useful in the treatment of autoimmune diseases and organ transplantation through the inhibitory action of T cells in inflammation.

引用

页码：1221 / 1226

页数：6

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