Automated quality control of emission-transmission misalignment for attenuation correction in myocardial perfusion imaging with SPECT-CT systems

被引:29
作者
Chen, J
Caputlu-Wilson, SF
Shi, HC
Galt, JR
Faber, TL
Garcia, EV
机构
[1] Emory Univ, Dept Radiol, Sch Med, Atlanta, GA 30322 USA
[2] Georgia Inst Technol, Atlanta, GA 30332 USA
[3] Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
关键词
attenuation correction; automated quality control; emission-transmission misalignment; myocardial perfusion imaging;
D O I
10.1016/j.nuclcard.2005.11.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Emission-transmission misalignment with single-photon emission computed tomography (SPECT)- computed tomography (CT) systems can impair attenuation correction (AC) in myocardial perfusion imaging. This study was performed to develop automated quality control (Auto-QC) to detect critical misalignment that can significantly impact AC. Methods and Results. Auto-QC was developed to segment myocardium and mediastinum from emission and transmission reconstructions, respectively. Myocardium-mediastinum mismatch was used as the quality-control index (QCI). The QCI threshold for acceptable AC was determined with NCAT (NURBS [nonuniform rational B-spline]- based cardiac torso phantom) simulation and verified with 2 patients with minimal misalignment. Compromised data sets, generated by shifting the attenuation maps by 0.5, 1.0, 1.5, and 2.0 pixels along left-right, up-down, and head-foot directions, respectively, were qualitatively and quantitatively compared with the unshifted data sets. Auto-QC was tested with the 2 verification patients and 41 additional patients. Shifts by more than 1 pixel along any direction compromised AC. Auto-QC with the QCI threshold (3%) had highly concordant results with manual quality control in the detection of critical misalignment (sensitivity of 88% and 90% and specificity of 93% and 95% for the tests by use of the 2 verification patients and 41 additional patients, respectively). Conclusion. QCI quantitatively represented the severity of misalignment. Auto-QC can help clinicians be aware of critical misalignment and can assist in realignment of SPECT and CT images.
引用
收藏
页码:43 / 49
页数:7
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