Novel polymeric solid-phase extraction material for complex biological matrices - Portable and disposable artificial kidney

被引：13

作者：

Davankov, VA ^{[1
]}

Pavlova, LA ^{[1
]}

Tsyurupa, MP ^{[1
]}

Tur, DR ^{[1
]}

机构：

[1] ULTRASCAN CORP,MOSCOW,RUSSIA

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 689卷 / 01期

关键词：

polystyrene; artificial kidney; Styrosorb;

D O I：

10.1016/S0378-4347(96)00307-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The replacement of conventional hemodialysis treatment for a patient with malfunctioning kidneys by providing him/her with a portable and disposable ''artificial kidney'' which is connected to implanted artery and veneous cannulas on a patient's wrist is discussed. During a continuous flow of brood, plasma diffuses through a plasmapheretic membrane, passes through a bed of plasmacompatible sorbent Styrosorb, and arrives at an ultrafiltration membrane. Vacuum-operated ultrafiltration removes excess water together with dissolved urea and other small molecules, and Stryosorb removes medium-sized toxic substances. The hemocompatibility of the sorbent is improved by chemical modification of the surface.

引用

页码：117 / 122

页数：6

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