Nested genes and increasing organizational complexity of metazoan genomes

被引：37

作者：

Assis, Raquel ^{[3
,4
]}

Kondrashov, Alexey S. ^{[3
,4
]}

Koonin, Eugene V. ^{[2
]}

Kondrashov, Fyodor A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, Sect Ecol Behavior & Evolut, La Jolla, CA 92093 USA

[2] Natl Lib Med, Natl Ctr Biotechnol Informat, Natl Inst Hlth, Bethesda, MD 20894 USA

[3] Univ Michigan, Ctr Computat Med & Biol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 10期

关键词：

D O I：

10.1016/j.tig.2008.08.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

引用

页码：475 / 478

页数：4

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