Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia

被引:26
作者
Baldassarre, D [1 ]
Amato, M [1 ]
Pustina, L [1 ]
Tremoli, E [1 ]
Sirtori, CR [1 ]
Calabresi, L [1 ]
Franceschini, G [1 ]
机构
[1] Univ Milan, Dept Pharmacol Sci, Ctr E Grossi Paoletti, I-20133 Milan, Italy
关键词
intima-media thickness; high-density lipoproteins hypoalphalipoproteinemia; hyperalphalipoproteinemia; preintrusive atherosclerosis;
D O I
10.1161/hq0202.104848
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94 +/- 0.06 versus 0.69 +/- 0.04 mm, P=0.004, and 1.86 +/- 0.16 versus 1.35 +/- 0.10 mm. P=0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71 +/- 0.04 and Max-IMT. 1.38 +/- 0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (n= 559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (<42 mg/dL) than in all the others. The measurement of carotid IMT in cases with HypoALP and HyperALP, and in a large series of hyperlipidemic patients, thus indicates that a low HDL-C is associated with significant pre-intrusive atherosclerosis, whereas a HDL-C level above average values does not lead to a further reduction of arterial wall thickening.
引用
收藏
页码:317 / 322
页数:6
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