Sorting out signals in fly endosomes

被引：20

作者：

Krämer, H ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA

来源：

TRAFFIC | 2002年 / 3卷 / 02期

关键词：

delivery; EGF receptor; exosomes; lysosomal MVBs; mono-ubiquitination; Notch; wingless;

D O I：

10.1034/j.1600-0854.2002.030201.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ligands and receptors that mediate cell-cell interactions during development are removed from the cell surface by endocytosis. Subsequently, many of these internalized proteins are detected in multivesicular bodies (MVBs). Recent work in different organisms has elucidated some aspects of MVB biogenesis and trafficking. This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila.

引用

页码：87 / 91

页数：5

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