Turning a tiger into a house cat:: using Legionella pneumophila to study Coxiella burnetii

被引：28

作者：

Vogel, JP ^{[1
]}

机构：

[1] Washington Univ, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 03期

关键词：

D O I：

10.1016/j.tim.2004.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding how Coxiella burnetii causes Q fever has proven to be exceedingly difficult owing to its obligate intracellular nature. Sequencing the C. burnetii genome revealed the presence of genes that could encode a type IV secretion system highly homologous to the Dot/lcm system in Legionella pneumophila. Recently, two groups have exploited this similarity by expressing the C. burnetii dot/icm homologues in a surrogate host, L. pneumophila, to determine their function.

引用

页码：103 / 105

页数：3

共 25 条

[1] Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells [J].

Christie, PJ ;

Vogel, JP .

TRENDS IN MICROBIOLOGY, 2000, 8 (08) :354-360

[2] Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth [J].

Coers, J ;

Kagan, JC ;

Matthews, M ;

Nagai, H ;

Zuckman, DM ;

Roy, CR .

MOLECULAR MICROBIOLOGY, 2000, 38 (04) :719-736

[3] The Legionella pneumophila LidA protein:: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity [J].

Conover, GM ;

Derré, I ;

Vogel, JP ;

Isberg, RR .

MOLECULAR MICROBIOLOGY, 2003, 48 (02) :305-321

[4] The Legionella pneumophila IcmR protein exhibits chaperone activity for IcmQ by preventing its participation in high-molecular-weight complexes [J].

Duménil, G ;

Isberg, RR .

MOLECULAR MICROBIOLOGY, 2001, 40 (05) :1113-1127

[5] Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism [J].

Fields, KA ;

Hackstadt, T .

MOLECULAR MICROBIOLOGY, 2000, 38 (05) :1048-1060

[6] The diverse habitats of obligate intracellular parasites [J].

Hackstadt, T .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (01) :82-87

[7] Developmental biology of Coxiella burnetii [J].

Heinzen, RA ;

Hackstadt, T ;

Samuel, JE .

TRENDS IN MICROBIOLOGY, 1999, 7 (04) :149-154

[8] FORMATION OF A NOVEL PHAGOSOME BY THE LEGIONNAIRES-DISEASE BACTERIUM (LEGIONELLA-PNEUMOPHILA) IN HUMAN-MONOCYTES [J].

HORWITZ, MA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (04) :1319-1331

[9] THE LEGIONNAIRES-DISEASE BACTERIUM (LEGIONELLA-PNEUMOPHILA) INHIBITS PHAGOSOME-LYSOSOME FUSION IN HUMAN-MONOCYTES [J].

HORWITZ, MA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (06) :2108-2126

[10] Coxiella burnetti exhibits morphological change and delays phagolysosomal fusion after internalization by J774A.1 cells [J].

Howe, D ;

Mallavia, LP .

INFECTION AND IMMUNITY, 2000, 68 (07) :3815-3821

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