Triterpene saponins of Genista ulicina Spach

被引：19

作者：

Boutaghane, Naima ^{[1
,2
]}

Voutquenne-Nazabadioko, Laurence ^{[1
]}

Harakat, Dominique ^{[1
]}

Simon, Alain

Kabouche, Zahia ^{[2
]}

机构：

[1] UFR Pharm, CNRS UMR 7312, ICMR, F-51687 Reims, France

[2] Univ Mentouri Constantine, Fac Sci Exactes, Lab Obtent Subst Therapeutiques, Constantine 25000, Algeria

来源：

PHYTOCHEMISTRY | 2013年 / 93卷

关键词：

Genista ulicina; Fabaceae; Triterpenoid saponins; Cytotoxic activity; QUINOLIZIDINE ALKALOIDS; SOYASAPONIN-I; FLAVONOIDS; PLANTS; ISOFLAVONOIDS; SESSILIFOLIA; ELUCIDATION; SAPOGENOL; TENERA;

D O I：

10.1016/j.phytochem.2013.03.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the n-BuOH extract of the aerial parts of Genista ulicina, six triterpene saponins, 3-O-beta-D-glucopyranosyl-olean-12-ene-3 beta,27,28,30-tetraol, 3-O-beta-D-glucopyranosyl-olean-12-ene-3 beta,27,28,29-tetraol, 3,29-di-O-beta-D-glucopyranosyl-olean-12-ene-3 beta,27,28,29-tetraol, 3-O-beta-D-glucopyranosyl-olean-12-ene-3 beta,28,29-triol-27-oic acid, 3-O-beta-D-glucopyranosyl-olean-12-ene-3 beta,27,28-triol-29-oic acid, and 3-O-beta-D-glucopyranosyl-14-H-27-nor-olean-12-ene-3 beta,28,29-triol, were isolated together with eight known triterpene saponins and six flavonoids. Their structures were established mainly by means of spectroscopic methods (1D and 2D-NMR as well as HR-ESI-MS). The n-BuOH extract, investigated for its antitumor growth inhibition of human colon cancer HT-29 cells, presented no significant activity (IC50 > 100 mu g). (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：176 / 181

页数：6

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