Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo

被引：26

作者：

Abdel-Mohsen, Mohamed ^{[1
]}

Deng, Xutao ^{[2
]}

Liegler, Teri ^{[1
]}

Guatelli, John C. ^{[3
,4
]}

Salama, Mohamed S. ^{[5
]}

Ghanem, Hussam El-din A. ^{[5
]}

Rauch, Andri ^{[6
,7
]}

Ledergerber, Bruno ^{[8
]}

Deeks, Steven G. ^{[1
]}

Guenthard, Huldrych F. ^{[8
]}

Wong, Joseph K. ^{[1
,9
]}

Pillai, Satish K. ^{[1
,2
,9
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Blood Syst Res Inst, San Francisco, CA USA

[3] Univ Calif San Diego, La Jolla, CA 92093 USA

[4] VA San Diego Healthcare Syst, San Diego, CA USA

[5] Ain Shams Univ, Fac Sci, Cairo, Egypt

[6] Univ Hosp Bern, Dept Infect Dis, CH-3010 Bern, Switzerland

[7] Univ Bern, Bern, Switzerland

[8] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland

[9] San Francisco VA Med Ctr, Dept Med, San Francisco, CA USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 01期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

PERSISTENT LCMV INFECTION; ANTIRETROVIRAL ACTIVITY; PEGINTERFERON ALPHA-2A; RESTRICTION FACTORS; EXPRESSION PROFILE; GENE-EXPRESSION; C VIRUS; SUPPRESSION; BLOCKADE;

D O I：

10.1128/JVI.02687-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Alpha interferon (IFN-alpha) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-alpha/ribavirin (IFN-alpha/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-alpha/riba in HIV/ hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4+ T cells was significantly correlated with viral load reduction during IFN-alpha/riba treatment (r(2) = 0.649; P < 0.016). Exogenous IFN-alpha induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia.

引用

页码：763 / 767

页数：5

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