Influence of Chronic Hyperglycemia on Cerebral Microvascular Remodeling An In Vivo Study Using Perfusion Computed Tomography in Acute Ischemic Stroke Patients

被引：47

作者：

Hou, Qinghua ^{[1
,4
]}

Zuo, Zhiyi ^{[2
]}

Michel, Patrik ^{[5
]}

Zhang, Yanrong ^{[1
,7
]}

Eskandari, Ashraf ^{[5
]}

Man, Fengyuan ^{[1
,8
]}

Gao, Qingcun ^{[4
]}

Johnston, Karen C. ^{[3
]}

Wintermark, Max ^{[1
,6
]}

机构：

[1] Univ Virginia, Dept Radiol, Neuroradiol Div, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Anesthesiol, Charlottesville, VA 22908 USA

[3] Univ Virginia, Dept Neurol, Charlottesville, VA 22908 USA

[4] Guangzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Guangzhou, Guangdong, Peoples R China

[5] CHU Vaudois, Dept Neurol, Vaudois, Switzerland

[6] CHU Vaudois, Dept Radiol, Vaudois, Switzerland

[7] Huazhong Univ Sci & Technol, Dept Ultrasound, Union Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China

[8] Capital Med Univ, Tongren Hosp, Dept Radiol, Beijing, Peoples R China

来源：

STROKE | 2013年 / 44卷 / 12期

关键词：

cerebrovascular disorders; diabetes mellitus; diabetic microangiopathy; perfusion imaging; stroke; TYPE-2; DIABETES-MELLITUS; CT; SCALE; ROLES; MRI;

D O I：

10.1161/STROKEAHA.113.003150

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background and Purpose To investigate the effect of chronic hyperglycemia on cerebral microvascular remodeling using perfusion computed tomography. Methods We retrospectively identified 26 patients from our registry of 2453 patients who underwent a perfusion computed tomographic study and had their hemoglobin A(1c) (HbA(1c)) measured. These 26 patients were divided into 2 groups: those with HbA(1c)>6.5% (n=15) and those with HbA(1c)6.5% (n=11). Perfusion computed tomographic studies were processed using a delay-corrected, deconvolution-based software. Perfusion computed tomographic values were compared between the 2 patient groups, including mean transit time, which relates to the cerebral capillary architecture and length. Results Mean transit time values in the nonischemic cerebral hemisphere were significantly longer in the patients with HbA(1c)>6.5% (P=0.033), especially in the white matter (P=0.005). Significant correlation (R=0.469; P=0.016) between mean transit time and HbA(1c) level was observed. Conclusions Our results from a small sample suggest that chronic hyperglycemia may be associated with cerebral microvascular remodeling in humans. Additional prospective studies with larger sample size are required to confirm this observation.

引用

页码：3557 / 3560

页数：4

共 15 条

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