Uveitis Subtypes in a German Interdisciplinary Uveitis Center - Analysis of 1916 Patients

Objective. Studies Oil the epidemiology of uveitis are rare and cohorts are small. We analyzed the frequencies of classified forms Of uveitis in all patients at our center. Methods. We studied 1916 consecutive patients with inflammatory eye disease. Data were analyzed regarding associated systemic disease, infection, ocular syndromes, anatomic localization, age, and sex. Results. In 59.1% of patients, a classified form of uveitis was observed:associated systemic diseases in 43.7%, the most frequent ones sarcoidosis (17.4%) and ankylosing spondylitis (16.9%); ocular syndromes in 34.3%, the most frequent HLA-B27-positive anterior uveitis (AU: 35.1%) and Fuchs uveitis syndrome (FUS; 34.3%); and infections in 22.4%, the Most frequent herpetic infections (46.1%) and toxoplasmosis (31.5%). We found AU in 45.4% of patients (15.4% HLA-B27-positive AU and 11.3% FUS), intermediate uveitis in 22.9% (unclassified 53.7% and multiple sclerosis 10.3%), and posterior Uveitis in 13.5% (24.7%, toxoplasmosis). Panuveitis was diagnosed in 6.2% of cases (Behcet's disease 12.6%, sarcoidosis 10.9%). The remaining 12.0% of cases showed extrauveal manifestations (scleritis, episcleritis, keratitis, optic neuritis, myositis, and orbital inflammation). Conclusion. We describe the largest cohort to (late of consecutive patients from a specialized uveitis center. The high frequency of classified disease, nearly 60% in our clinic, shows the usefulness of an interdisciplinary approach, oriented on anatomic presentation. (First Release Dec 15 2008; J Rheumatol 2009;36:127-36; doi: 10.3899/jrheum.080102)